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Folate Binding Protein (LK26)
Clone: LK-26

The LK26 antigen is a cell surface glycoprotein (Mr 35 –40 Kd) of normal placenta and gestational choriocarcinoma that shows highly restricted distribution in normal tissues, being expressed primarily in a subset of simple epithelia 1. Ovarian carcinomas derived from coelomic epithelium show the most consistent and strongest immunostaining. Ovarian tumors of sex cord, germ cell and stromal origin are generally LK26-. LK26 is not found in normal fetal or adult ovary, however it may be present in the lining epithelia of some benign ovarian cysts. Mesotheliomas, which share a common mesothelial origin with LK26+ ovarian tumors, express no or low levels of LK26. Other epithelial cancers may express LK26 in a subset of cases and generally show heterogeneous or weak immunostaining such as endometrial, colorectal, breast, lung and renal carcinomas. Tests with cultured cells showed that the LK26 proteins expressed in choriocarcinomas and ovarian cancer cells are biochemically similar and transfection experiments identified LK26 as an adult-type high-affinity folate-binding protein.
Master Cat. No. 619 Cat. No. 619-01 Clone: LK-26

Catalog # Format Quantity Price
619-01   Concentrate   1ml   395.10  

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