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Low-density lipoprotein receptor-related protein 6 (LRP6) polyclonal antibody
 
Cat. No. Format Size Price
PAB-10779 Purified 100 µg 275 Euro
Animal ID: 
RB1837-1838 
 
Host: 
Rabbit 
 
Reactivity: 
human 
 
Buffers: 
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS. 
 
Storage: 
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles. 
 
Application: 
Tested by peptide-specific ELISA (1:1,000). 
 
Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1546 - 1560 [RMTSVATAKGYTSDL] of the human low-density lipoprotein receptor-related protein 6 (LRP6) protein. 
Accession number:
NM_002336 
Description:
Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low density lipoprotein receptor (LDLR) family which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LRP6 contains EGF and LDLR repeats in the extracellular domain and is structurally similar to LRP5, a proposed candidate gene for type 1 diabetes.
Alternative Name(s):
low density lipoprotein-related protein 6 
References:
 
  1. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X: LDL-receptor-related proteins in Wnt signal transduction. Nature 407(6803): 530-535 (2000).
  2. Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem. Biophys. Res. Commun. 248(3): 879-888 (1998).

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