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low-density lipoprotein receptor-related protein 5 (LRP5) polyclonal antibody
 
Cat. No. Format Size Price
PAB-10778 Purified 100 µg 275 Euro
Animal ID: 
RB1835-1836 
 
Host: 
Rabbit 
 
Reactivity: 
human 
 
Buffers: 
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS. 
 
Storage: 
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles. 
 
Application: 
Tested by peptide-specific ELISA (1:1,000). 
 
Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1553 - 1568 [SASRWKASKYYLDLNC] of the human low-density lipoprotein receptor-related protein 5 (LRP5) protein. 
Accession number:
NM_002335 
Description:
Low-density lipoprotein receptor-related protein 5 (LRP5) is a member of the low density lipoprotein receptor (LDLR) family which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LRP5 cause several human diseases, including bone mineral density variability 1 endosteal hyperostosis, autosomal dominant osteopetrosis type I, osteoporosis-pseudoglioma syndrome and van Buchem disease type 2. The V171 mutation in LRP5 causes high bone density by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling.
Alternative Name(s):
low density lipoprotein receptor-related protein 5, HBM, LR3, LRP7, OPPG, BMND1, low density lipoprotein receptor-related protein 7 
References:
 
  1. Van Hul E, Gram J, Bollerslev J, Van Wesenbeeck L, Mathysen D, Andersen PE, Vanhoenacker F, Van Hul W: Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13. J. Bone Miner. Res. 17(6): 1111-1117 (2002).
  2. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP: High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346(20): 1513-1521 (2002).
  3. Okubo M, Horinishi A, Kim DH, Yamamoto TT, Murase T: Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene. Hum. Mutat. 19(2): 186 (2002).
  4. Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, Folz C, Manning SP, Swain PM, Zhao SC, Eustace B, Lappe MM, Spitzer L, Zweier S, Braunschweiger K, Benchekroun Y, Hu X, Adair R, Chee L, FitzGerald MG, Tulig C, Caruso A, Tzellas N, Bawa A, Franklin B, McGuire S, Nogues X, Gong G, Allen KM, Anisowicz A, Morales AJ, Lomedico PT, Recker SM, Van Eerdewegh P, Recker RR, Johnson ML: A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70(1): 11-19 (2002).
  5. Chen D, Lathrop W, Dong Y: Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human. Genomics 55(3): 314-321 (1999).
  6. Dong Y, Lathrop W, Weaver D, Qiu Q, Cini J, Bertolini D, Chen D: Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem. Biophys. Res. Commun. 251(3): 784-790 (1998).
  7. Hey PJ, Twells RC, Phillips MS, Yusuke Nakagawa, Brown SD, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF: Cloning of a novel member of the low-density lipoprotein receptor family. Gene 216(1): 103-111 (1998).

 

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