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Anti-Alivin 1 Polyclonal Antibody

 Catalog Number:         25-24357                                                                                  Price: 282 Euro / 333 USD

 Lot Number:                R5711

 Quantity:                     100 mg in 100 ml (1 mg/ml) in PBS containing 0.02% sodium azide.

 Description:                 A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families.  Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.

 Host Species:              Rabbit

 Specificity:                   Reacts with residues 449-464 [TGDASADDRKAGKRVV] of mouse and rat Alivin 1.  81% sequence identity to human.  Detects bands of 63 ands 66 kDa in brain with the majority of the immunoreactivity in the nuclear fraction. 

Application:                 Western blot – Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

 Format:                       Affinity purified IgG

 Storage:                       Maintain at +2-8°C for 3 months or at -20°C for longer periods.  Stable for 1 year. Avoid repeated freeze-thaw cycles.

 Reference:                   Ono,T. et. al.  J. Neurosci. 23 (13), 5887-5896 (2003).

 

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Last modified: 05/19/16